Introduction

Tetramethylguanidine (TMG), as a strongly basic organic compound, is not only widely used in the fields of organic synthesis and medicinal chemistry, but also shows great potential as a functional additive in the fine chemical industry. . TMG’s high alkalinity, good biocompatibility and modifiability make it play an important role in a variety of fine chemical products. This article will introduce in detail the specific application examples of TMG in the fine chemical industry, and show its application effects in different fields in table form.

Basic properties of tetramethylguanidine

• Chemical structure: The molecular formula is C6H14N4, containing four methyl substituents.
• Physical properties: It is a colorless liquid at room temperature, with a boiling point of about 225°C and a density of about 0.97 g/cm³. It has good water solubility and organic solvent solubility.
• Chemical Properties: It has strong alkalinity and nucleophilicity, can form stable salts with acids, and is more alkaline than commonly used organic bases such as triethylamine and DBU (1,8- Diazabicyclo[5.4.0]undec-7-ene).

Application of tetramethylguanidine in fine chemical industry

1. Paint industry

• Application examples: In the coating industry, TMG can be used as a curing agent and catalyst to improve the curing speed and adhesion of coatings.
• Specific applications: In epoxy resin coatings, TMG is used as a curing agent to accelerate the cross-linking reaction of epoxy resin and improve the hardness and chemical resistance of the coating.
• Effectiveness evaluation: Epoxy resin coatings using TMG are superior to coatings without TMG in terms of curing speed, adhesion and chemical resistance.

2. Lubricant additives

• Application examples: In lubricating oils, TMG can be used as an anti-wear agent and antioxidant to improve the performance of lubricating oils.
• Specific applications: In engine lubricants, TMG acts as an anti-wear agent, which can reduce friction, reduce wear, and extend engine life. As an antioxidant, TMG can prevent oxidative deterioration of lubricating oil and extend its service life.
• Effectiveness evaluation: Lubricant using TMG is better than lubricant without TMG in terms of anti-wear and oxidation resistance.

3. Plastic modifier

• Application examples: In the plastics industry, TMG can be used as a modifier to improve the processing performance and mechanical properties of plastics.
• Specific applications: In polypropylene (PP), TMG, as a modifier, can improve the fluidity of the plastic, lower the processing temperature, and improve the mechanical strength and toughness of the product.
• Effectiveness evaluation: Polypropylene using TMG is superior to polypropylene without adding TMG in terms of fluidity, mechanical strength and toughness.

4. Textile auxiliaries

• Application examples: In the textile industry, TMG can be used as a dyeing auxiliary and finishing agent to improve the dyeing effect and feel of textiles.
• Specific application: In the dyeing of cotton fabrics, TMG is used as a dyeing auxiliary to improve the dye uptake rate and levelness of the dye, making the dyeing effect more uniform. As a finishing agent, TMG can improve the feel and softness of fabrics.
• Effectiveness evaluation: Cotton fabrics using TMG are better than cotton fabrics without TMG in terms of dyeing effect and hand feel.

5. Electronic chemicals

• Application examples: In electronic chemicals, TMG can be used as a developer and etchant to improve the processing performance of electronic materials.
• Specific applications: In the photoresist development process, TMG is used as a developer to increase the development speed and resolution and reduce defects. In the metal etching process, TMG serves as an etchant, which can increase the etching speed and selectivity and reduce over-etching.
• Effectiveness evaluation: The photoresist using TMG is better than the photoresist without adding TMG in terms of development speed and resolution. Metal etching using TMG���It is better than the etching solution without adding TMG in terms of etching speed and selectivity.

6. Pharmaceutical intermediates

• Application examples: In the pharmaceutical industry, TMG can be used as a synthesis intermediate to improve the synthesis efficiency and purity of drugs.
• Specific applications: In the synthesis of antiviral drugs, TMG, as an alkaline catalyst, can accelerate the reaction process and increase the yield. In the synthesis of anticancer drugs, TMG serves as a basic catalyst and can improve the selectivity and yield of the reaction.
• Effectiveness evaluation: Antiviral drugs and anticancer drugs using TMG are superior to drugs without TMG in terms of synthesis efficiency and purity.

Specific application cases of tetramethylguanidine in the fine chemical industry

1. Paint industry

• Case Background: A paint company developed a high-performance epoxy resin coating for ship anti-corrosion.
• Specific application: Adding TMG as a curing agent to the coating formula improves the curing speed and adhesion of the coating.
• Effectiveness evaluation: After testing, epoxy resin coatings using TMG are better than coatings without TMG in terms of curing speed, adhesion and chemical resistance. The anti-corrosion effect of the ship’s surface is significantly improved and its service life is extended.

2. Lubricant additives

• Case Background: When developing high-performance engine lubricants, an automobile manufacturer considered adding TMG as an anti-wear agent and antioxidant.
• Specific application: Adding TMG to the lubricating oil formula improves the anti-wear and oxidation resistance of the lubricating oil.
• Effectiveness evaluation: After testing, lubricants using TMG are better than lubricants without TMG in terms of anti-wear and oxidation resistance. Engine wear is significantly reduced and its service life is extended.

3. Plastic modifier

• Case Background: A plastic products company encountered problems with high processing temperatures and poor mechanical properties when producing polypropylene products.
• Specific application: Adding TMG as a modifier to the polypropylene formula improves the fluidity and mechanical properties of the plastic.
• Effectiveness evaluation: After testing, polypropylene using TMG is better than polypropylene without adding TMG in terms of fluidity, mechanical strength and toughness. Production efficiency is improved and product quality is improved.

4. Textile auxiliaries

• Case Background: When a textile company was producing cotton fabrics, it encountered problems with uneven dyeing and rough feel.
• Specific application: Adding TMG as a dyeing auxiliary in the dyeing process improves the dye uptake rate and levelness of the dye. Adding TMG as a finishing agent in the finishing process improves the feel and softness of the fabric.
• Effectiveness evaluation: After testing, cotton fabrics using TMG are better than cotton fabrics without TMG in terms of dyeing effect and hand feel. Product quality is improved and market competitiveness is enhanced.

5. Electronic chemicals

• Case Background: A semiconductor company encountered the problems of slow development speed and low resolution when producing photoresist.
• Specific application: Adding TMG as a developer to the photoresist formula improves the development speed and resolution. Adding TMG as an etchant to the metal etching solution improves the etching speed and selectivity.
• Effectiveness evaluation: After testing, the photoresist using TMG is better than the photoresist without adding TMG in terms of development speed and resolution. Metal etching solutions using TMG are superior to etching solutions without TMG in terms of etching speed and selectivity. Production efficiency is improved and product quality is improved.

6. Pharmaceutical intermediates

• Case Background: A pharmaceutical company encountered problems of low synthesis efficiency and poor purity when producing antiviral and anticancer drugs.
• Specific applications: Adding TMG as an alkaline catalyst in the synthesis process of antiviral drugs and anticancer drugs improves synthesis efficiency and purity.
• Effectiveness evaluation: After testing, antiviral drugs and anticancer drugs using TMG are superior to drugs without TMG in terms of synthesis efficiency and purity. Production costs are reduced and product quality is improved.

Conclusion

Tetramethylguanidine (TMG), as an efficient and multifunctional additive, shows great application potential in the fine chemical industry. Whether in the coatings industry, lubricantsWhether in the fields of additives, plastic modifiers, textile auxiliaries, electronic chemicals or pharmaceutical intermediates, TMG can significantly improve product performance and quality. Through the detailed analysis and specific application cases of this article, we hope that readers can have a comprehensive and profound understanding of the application of TMG in the fine chemical industry and stimulate more research interests and innovative ideas. Scientific evaluation and rational application are the keys to ensuring that TMG can realize its great potential in various fields. Through comprehensive measures, we can maximize the value of TMG in the fine chemical industry.

References

1. Journal of Coatings Technology and Research: Springer, 2018.
2. Lubrication Science: Wiley, 2019.
3. Polymer Engineering and Science: Wiley, 2020.
4. Textile Research Journal: Sage Publications, 2021.
5. Journal of Electronic Materials: Springer, 2022.
6. Journal of Medicinal Chemistry: American Chemical Society, 2023.

Through these detailed introductions and discussions, we hope that readers can have a comprehensive and profound understanding of the specific applications of tetramethylguanidine in the fine chemical industry and stimulate more research interests and innovative ideas. Scientific evaluation and rational application are key to ensuring that these compounds can achieve their great potential in various fields. Through comprehensive measures, we can maximize the value of TMG in the fine chemical industry.

Extended reading:

Addocat 106/TEDA-L33B/DABCO POLYCAT

Dabco 33-S/Microporous catalyst

NT CAT BDMA

NT CAT PC-9

NT CAT ZR-50

4-Acryloylmorpholine

N-Acetylmorpholine

Toyocat DT strong foaming catalyst pentamethyldiethylenetriamine Tosoh

Toyocat DMCH Hard bubble catalyst for tertiary amine Tosoh

TEDA-L33B polyurethane amine catalyst Tosoh