Structural formula

Business number	0136
Molecular formula	C15H18N4O5
Molecular weight	334.33
label	Mitomycin, mitomycin, Zilinomycin, Pyrimycin, [1aR-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5- methylazirino[2′,3′:3,4]pyrrolo[1,2-α]indole-4,7-dione, 6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methox-5-methylazirino[2′,3′:3,4]pyrrolo[1,2-, antineoplastic drugs, antibiotic

• Numbering system
• Physical property data
• Toxicological data
• Ecological data
• Molecular structure data
• Computing chemical data
• More
  • Properties and Stability
  • Storage method
  • Synthesis method
  • Purpose

Numbering system

CAS number:50-07-7

MDL number:MFCD00078109

EINECS number:200-008-6

RTECS number:None

BRN number:7231816

PubChem number:24896555

Physical property data

1. Properties: blue-purple shiny crystals or crystalline powder, odorless. The solid is stable, but easily deactivated in acidic and alkaline solutions

2. Density (g/mL, 25/4℃): Uncertain

3. Relative vapor density ( g/mL, air=1): Uncertain

4. Melting point (ºC): >360

5. Boiling point (ºC, normal pressure): Uncertain

6. Boiling point (ºC, 5.2 kPa): Uncertain

7. Refractive index: Uncertain

8. Flash point (ºC): Uncertain

9. Specific optical rotation (º): Uncertain

10. Autoignition point or ignition temperature (ºC): Uncertain

11. Vapor pressure (kPa, 25 ºC): Uncertain

12. Saturated vapor pressure (kPa, 60 ºC): Uncertain

13. Heat of combustion (KJ/mol): Uncertain

14. Critical temperature (ºC): Uncertain

15. Critical pressure (KPa): Uncertain

16. Log value of oil-water (octanol/water) partition coefficient : Uncertain

17. Explosion upper limit (%, V/V): Uncertain

18. Explosion lower limit (%, V/V): Uncertain

19. Solubility: This product is soluble in water (H₂O: 4 mL/vial Stock solutions should be filter sterilized and stored at 2-8 °C in the dark., clear to slightly hazy, blue to purple), methanol, acetone and ethyl acetate and other organic solvents, slightly soluble in benzene, diethyl ether and carbon tetrachloride, but insoluble in petroleum ether

Toxicological data

None

Ecological data

None

MinsSubstructure data

1. Molar refractive index: 80.79

2. Molar volume (cm³/mol): 213.6

3. Isotonic specific volume (90.2K ): 633.5

4. Surface tension (dyne/cm): 77.2

5. Polarizability (10-24cm3): 32.02

Compute chemical data

1. Hydrophobic parameter calculation reference value (XlogP): -0.4

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 8

p>

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: 42

6. Topological molecular polar surface area (TPSA): 147

7. Number of heavy atoms: 24

8. Surface charge: 0

9. Complexity: 757

10. Isotopic atoms Quantity: 0

11. Determine the number of atomic stereocenters: 4

12. Uncertain number of atomic stereocenters: 0

13. Determine chemical bond positions Number of stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a cool, dark place.

Synthesis method

Produced by fermentation method. Mitomycin A, B, and C can be extracted from the culture medium of Strepto-myces caespitosus. my country extracted it from its own isolate of actinomycete H2760 strain, also known as Zilinomycin, which is the same as mitomycin C reported abroad.

Purpose

This product has a wide anti-tumor spectrum and is effective in gastric cancer and breast cancer. It has certain effects on lung cancer, liver cancer, malignant lymphoma, Hodgkin’s disease, reticulocyte sarcoma, uterine cancer, leukemia, intestinal cancer and pancreatic cancer, but the remission period is short. Combination with urokinase can improve the efficacy. This product acts quickly, but the number of treatment operators is not high and the toxicity is high. This product, along with bleomycin and its derivatives perimecin, are antibiotic anticancer drugs that damage DNA. They can depolymerize cellular DNA and inhibit DNA replication in proliferating cells. The LD50 of intravenous injection in mice is 5ml/kg.

extended-reading:https://www.bdmaee.net/wp-content/uploads/2022/08/22.jpg
extended-reading:https://www.newtopchem.com/archives/category/products/semi-rigid-foams-catalyst
extended-reading:https://www.bdmaee.net/wp-content/uploads/2022/08/Polyurethane-Catalyst-A33-CAS-280-57-9–33-LV.pdf
extended-reading:https://www.bdmaee.net/nt-cat-e-129-elastomer-catalyst-elastomer-catalyst-nt-cat-e-129/
extended-reading:https://www.bdmaee.net/dibutyloxostannane/
extended-reading:https://www.bdmaee.net/methyl-tin-maleate-powder/
extended-reading:https://www.morpholine.org/category/morpholine/flumorph/
extended-reading:https://www.bdmaee.net/fomrez-ul-28-catalyst-dimethyltin-dioctadecanoate-momentive-2/
extended-reading:https://www.cyclohexylamine.net/tertiary-amine-catalyst-xd-103-catalyst-xd-103/
extended-reading:https://www.newtopchem.com/archives/40000