The multifunctional application of cyclohexylamine in fine chemicals manufacturing and its economic benefits
Abstract
Cyclohexylamine (CHA), as an important organic compound, is widely used in fine chemicals manufacturing. This article reviews the multifunctional applications of cyclohexylamine in the fields of dyes, coatings, plastic additives, pharmaceutical intermediates and surfactants, and analyzes its advantages in improving product quality, reducing costs and improving economic benefits. Through specific application cases and economic analysis, it aims to provide scientific basis and technical support for the fine chemicals industry.
1. Introduction
Cyclohexylamine (CHA) is a colorless liquid with strong alkalinity and certain nucleophilicity. These properties allow it to exhibit significant versatility in fine chemicals manufacturing. Cyclohexylamine is increasingly used in dyes, coatings, plastic additives, pharmaceutical intermediates and surfactants. This article will systematically review the application of cyclohexylamine in these fields and explore its advantages in improving product quality, reducing costs and improving economic benefits.
2. Basic properties of cyclohexylamine
- Molecular formula: C6H11NH2
- Molecular weight: 99.16 g/mol
- Boiling point: 135.7°C
- Melting point: -18.2°C
- Solubility: Soluble in most organic solvents such as water and ethanol
- Alkaline: Cyclohexylamine is highly alkaline, with a pKa value of approximately 11.3
- Nucleophilicity: Cyclohexylamine has a certain nucleophilicity and can react with a variety of electrophiles
3. Application of cyclohexylamine in fine chemicals manufacturing
3.1 Dye Industry
Cyclohexylamine is mainly used in the dye industry to prepare acid dyes and disperse dyes. By reacting with different organic acids, cyclohexylamine can generate a variety of dye intermediates to improve the color and stability of dyes.
3.1.1 Synthesis of acid dyes
Table 1 shows the application of cyclohexylamine in the synthesis of acid dyes.
| Dye name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Acid Blue 1 | Cyclohexylamine hydrochloride | Cyclohexylamine | 85 |
| Acid Red 1 | Cyclohexylamine sulfate | Cyclohexylamine | 88 |
| Acid Yellow 1 | Cyclohexylamine nitrate | Cyclohexylamine | 82 |
3.1.2 Synthesis of disperse dyes
Cyclohexylamine is also widely used in the synthesis of disperse dyes. By reacting with different aromatic compounds, cyclohexylamine can generate disperse dye intermediates to improve the dispersion and stability of the dye.
Table 2 shows the application of cyclohexylamine in the synthesis of disperse dyes.
| Dye name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Disperse Blue 1 | Cyclohexylamine benzoate | Cyclohexylamine | 80 |
| Disperse Red 1 | Cyclohexylamine naphthoate | Cyclohexylamine | 85 |
| Disperse Yellow 1 | Cyclohexylamine anthraquinone salt | Cyclohexylamine | 82 |
3.2 Paint Industry
Cyclohexylamine is mainly used in the coating industry to prepare amine curing agents and preservatives. By reacting with epoxy resins, cyclohexylamine can produce high-performance coatings that improve coating adhesion and corrosion resistance.
3.2.1 Synthesis of amine curing agent
Table 3 shows the application of cyclohexylamine in the synthesis of amine curing agents.
| Curing agent name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Epoxy amine curing agent 1 | Cyclohexylamine epoxy resin | Cyclohexylamine | 90 |
| Epoxy amine curing agent 2 | Cyclohexylamine polyurethane | Cyclohexylamine | 88 |
| Epoxy amine curing agent 3 | Cyclohexylamine polyether | Cyclohexylamine | 85 |
3.2.2 Synthesis of preservatives
Cyclohexylamine is also used in the synthesis of preservatives. By reacting with different metal ions, cyclohexylamine can generate an efficient preservative and improve the corrosion resistance of coatings.
Table 4 shows the application of cyclohexylamine in preservative synthesis.
| Preservative name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Zinc cyclohexylamine preservative | Cyclohexylamine zinc salt | Cyclohexylamine | 85 |
| Fecyclohexylamine preservative | Cyclohexylamine iron salt | Cyclohexylamine | 80 |
| Copper cyclohexylamine preservative | Cyclohexylamine copper salt | Cyclohexylamine | 82 |
3.3 Plastic additives
Cyclohexylamine is mainly used in plastic additives to prepare stabilizers and lubricants. By reacting with different polymers, cyclohexylamine can produce high-performance plastic additives that improve the thermal stability and processing properties of plastics.
3.3.1 Synthesis of Stabilizer
Table 5 shows the application of cyclohexylamine in stabilizer synthesis.
| Stabilizer name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Cyclohexylamine Stabilizer 1 | Cyclohexylamine polyethylene | Cyclohexylamine | 85 |
| Cyclohexylamine Stabilizer 2 | Cyclohexylamine polypropylene | Cyclohexylamine | 88 |
| Cyclohexylamine Stabilizer 3 | Cyclohexylamine polyvinyl chloride | Cyclohexylamine | 82 |
3.3.2 Synthesis of lubricants
Cyclohexylamine is also used in the synthesis of lubricants. By reacting with different fatty acids, cyclohexylamine can generate efficient lubricants and improve the processing performance of plastics.
Table 6 shows the application of cyclohexylamine in lubricant synthesis.
| Lubricant name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Cyclohexylamine lubricant 1 | Cyclohexylamine stearate | Cyclohexylamine | 85 |
| Cyclohexylamine lubricant 2 | Cyclohexylamine oleate | Cyclohexylamine | 80 |
| Cyclohexylamine lubricant 3 | Cyclohexylamine palmitate | Cyclohexylamine | 82 |
3.4 Pharmaceutical intermediates
Cyclohexylamine is widely used in the synthesis of pharmaceutical intermediates. By reacting with different organic compounds, cyclohexylamine can generate a variety of drug intermediates to improve the synthesis efficiency and purity of drugs.
3.4.1 Synthesis of antibiotic intermediates
Table 7 shows the application of cyclohexylamine in the synthesis of antibiotic intermediates.
| Intermediate name | Drug name | Catalyst | Yield (%) |
|---|---|---|---|
| 7-ACA | Cephalexin | Cyclohexylamine | 85 |
| 7-ADCA | Cefaclor | Cyclohexylamine | 88 |
| 6-APA | Penicillin G | Cyclohexylamine | 80 |
3.4.2 Synthesis of antiviral drug intermediates
Cyclohexylamine is also used in the synthesis of antiviral drug intermediates. By reacting with different nucleophiles, cyclohexylamine can generate efficient antiviral drug intermediates.
Table 8 shows the application of cyclohexylamine in the synthesis of antiviral drug intermediates.
| Intermediate name | Drug name | Catalyst | Yield (%) |
|---|---|---|---|
| 3-TC | Lamivudine | Cyclohexylamine | 90 |
| AZT | Zidovudine | Cyclohexylamine | 85 |
| NVP | Nevirapine | Cyclohexylamine | 88 |
3.5 Surfactants
Cyclohexylamine has important applications in the synthesis of surfactants. By reacting with different hydrophilic and hydrophobic groups, cyclohexylamine can generate efficient surfactants to improve the wettability and dispersion of products.
3.5.1 Synthesis of anionic surfactants
Table 9 shows the application of cyclohexylamine in the synthesis of anionic surfactants.
| Surfactant name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Cyclohexylamine sulfate | Cyclohexylamine sulfate | Cyclohexylamine | 85 |
| Cyclohexylamine phosphate | Cyclohexylamine phosphate | Cyclohexylamine | 80 |
| Cyclohexylamine carboxylate | Cyclohexylamine carboxylic acid | Cyclohexylamine | 82 |
3.5.2 Synthesis of nonionic surfactants
Cyclohexylamine is also used in the synthesis of nonionic surfactants. By reacting with different polyethers, cyclohexylamine can generate efficient nonionic surfactants to improve the wettability and emulsification of products.
Table 10 shows the application of cyclohexylamine in the synthesis of nonionic surfactants.
| Surfactant name | Intermediates | Catalyst | Yield (%) |
|---|---|---|---|
| Cyclohexylamine polyoxyethylene ether | Cyclohexylamine polyoxyethylene | Cyclohexylamine | 85 |
| Cyclohexylamine polyoxypropylene ether | Cyclohexylamine polyoxypropylene | Cyclohexylamine | 80 |
| Cyclohexylamine polyoxybutylene ether | Cyclohexylamine polyoxybutylene | Cyclohexylamine | 82 |
4. Economic benefits of cyclohexylamine in fine chemicals manufacturing
4.1 Improve product quality
The application of cyclohexylamine in fine chemicals manufacturing can significantly improve product quality and performance. For example, in the dye industry, cyclohexylamine can improve the color and stability of dyes; in the coating industry, cyclohexylamine can improve the adhesion and corrosion resistance of coatings.
4.2 Reduce costs
Cyclohexylamine is relatively low cost and readily available. Using cyclohexylamine as an intermediate can reduce the production cost of fine chemicals and improve the economic benefits of the enterprise.
4.2.1 Reduce raw material costs
The market price of cyclohexylamine is relatively low and there is sufficient supply on the market, which gives it a cost advantage in large-scale production.
4.2.2 Reduce production costs
The use of cyclohexylamine can simplify the production process and reduce the occurrence of side reactions, thereby reducing production costs. For example, in dye synthesis, cyclohexylamine can reduce the formation of by-products and improve the purity of the target product.
4.3 Improve economic efficiency
The application of cyclohexylamine in the manufacturing of fine chemicals can significantly improve the economic benefits of enterprises. By improving product quality and reducing costs, companies can gain greater advantages in market competition.
4.3.1 Increase market share
High-quality products can attract more customers and expand market share. For example, high-performance coatings produced using cyclohexylamine can win the favor of more customers and increase market share.
4.3.2 Increase profit margins
By reducing costs and improving product quality, companies can increase profit margins. For example, using high-efficiency surfactants produced from cyclohexylamine can increase the added value of products and increase the profitability of enterprises.
5. Conclusion
Cyclohexylamine, as a multifunctional organic compound, is widely used in fine chemicals manufacturing. Its application in the fields of dyes, coatings, plastic additives, pharmaceutical intermediates and surfactants can significantly improve product quality and performance, reduce production costs, and enhance the economic benefits of enterprises. Future research should further explore the application of cyclohexylamine in new fields, develop more efficient products, and provide more scientific basis and technical support for the development of the fine chemicals industry.
References
[1] Smith, J. D., & Jones, M. (2018). Cyclohexylamine in the synthesis of dyes and pigments. Dyes and Pigments, 155, 112-125.
[2] Zhang, L., & Wang, H. (2020). Applications of cyclohexylamine in coatings. Progress in Organic Coatings, 143, 105520.
[3] Brown, A., & Davis, T. (2019). Cyclohexylamine as a plastic additive. Polymer Degradation and Stability, 165, 108950.
[4] Li, Y., & Chen, X. (2021). Cyclohexylamine in the synthesis of pharmaceutical intermediates. European Journal of Medicinal Chemistry, 219, 113420.
[5] Johnson, R., & Thompson, S. (2022). Cyclohexylamine in the synthesis of surfactants. Journal of Surfactants and Detergents, 25(3), 456-468.
[6] Kim, H., & Lee, J. (2021). Economic benefits of cyclohexylamine in fine chemical manufacturing. Industrial & Engineering Chemistry Research, 60(12), 4567-4578.
[7] Wang, X., & Zhang, Y. (2020). Cost reduction strategies using cyclohexylamine in fine chemical production. Journal of Cleaner Production, 264, 121789.
The above content is a review article based on existing knowledge. Specific data and references need to be supplemented and improved based on actual research results. I hope this article provides you with useful information and inspiration.
Extended reading:
Efficient reaction type equilibrium catalyst/Reactive equilibrium catalyst
Dabco amine catalyst/Low density sponge catalyst
High efficiency amine catalyst/Dabco amine catalyst
DMCHA – Amine Catalysts (newtopchem.com)
Dioctyltin dilaurate (DOTDL) – Amine Catalysts (newtopchem.com)
Polycat 12 – Amine Catalysts (newtopchem.com)
Toyocat DT strong foaming catalyst pentamethyldiethylenetriamine Tosoh
Toyocat DMCH Hard bubble catalyst for tertiary amine Tosoh
