probenecid – Amine Catalysts https://www.newtopchem.com The Leading Supplier of China Amine Catalysts Fri, 07 Jun 2024 08:21:34 +0000 zh-Hans hourly 1 https://wordpress.org/?v=6.1.7 https://www.newtopchem.com/wp-content/uploads/2023/12/1.jpg probenecid – Amine Catalysts https://www.newtopchem.com 32 32 probenecid https://www.newtopchem.com/archives/49589 Fri, 07 Jun 2024 08:21:34 +0000 http://www.newtopchem.com/archives/49589 Probenecid Structural Formula

Structural formula

Business number 018W
Molecular formula C13H19NO4S
Molecular weight 285.36
label

p-(dipropylsulfamic acid) benzoic acid,

p-(Dipropylsulfamoyl)benzoic acid

Numbering system

CAS number:57-66-9

MDL number:MFCD00038402

EINECS number:200-344-3

RTECS number:DG9400000

BRN number:None

PubChem number:24898976

Physical property data

1. Appearance: white crystalline powder .


2. Density ( g/mL,25/4℃) : Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point ( ºC): 194-196


5. Boiling point ( ºC,Normal pressure): Undetermined


6. Boiling point ( ºC,5.2kPa): Undetermined


7. Refractive Index: Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Not OK


11. Vapor pressure (kPa,25ºC): Undetermined


12. Saturation vapor pressure (kPa,60ºC): Undetermined


13. heat of combustion (KJ/mol): Not OK


14. Critical temperature (ºC): Undetermined


15. Critical Pressure (KPa): Undetermined


16. Oil and water (octanol/Water) partition coefficient pair Value: Undetermined


17. Explosion limit (%,V/V): Not OK


18. Lower explosion limit (%,V/V): Undetermined


19. Solubility: soluble in acetone , slightly soluble in ethanol or chloroform, almost insoluble in water. Soluble in dilute sodium hydroxide solution, almost insoluble in dilute acid. Odorless, slightly bitter taste.

Toxicological data

None

Ecological data

None

Molecular structure data

5. Molecular property data:


1. Molar refractive index: 73.50


2. Molar volume (m3/mol）：233.5


3. isotonic specific volume (90.2K):610.4


4. Surface Tension (dyne/cm):46.7


5. Polarizability(10-24cm3):29.14


Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 5

4. Number of rotatable chemical bonds: 7

5. Number of tautomers: none

6. Topological molecule polar surface area 83.1

7. Number of heavy atoms: 19

8. Surface charge: 0

9. Complexity: 374

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed in4 Store dry at ℃.

Synthesis method

p-Toluenesulfonamide is oxidized to p-carboxybenzenesulfonamide by sodium dichromate, and then used bromopropane Alkylation reaction, the resulting probenecid sodium is acidified with acetic acid to obtain probenecid.

Purpose

Anti-gout drugs. This product is an organic acid with strong fat solubility. It is excreted from the renal tubules and is easily absorbed back into the body. Therefore, in the presence of propanesulfonate, the operation of certain organic acids in the body’s renal tubules will be inhibited, reducing the excretion of other organic acids. Therefore, it is safe and effective for the treatment of chronic gout. It has no effect on the pain and inflammation of acute gout and is not suitable for acute gout.

extended-reading:https://www.cyclohexylamine.net/2-2-dimethylaminoethylmethylaminoethanol/
extended-reading:https://www.bdmaee.net/di-n-octyl-tin-dilaurate/
extended-reading:https://www.bdmaee.net/wp-content/uploads/2022/08/130-2.jpg
extended-reading:https://www.cyclohexylamine.net/sponge-foaming-catalyst-smp-low-density-sponge-catalyst-smp/
extended-reading:https://www.cyclohexylamine.net/category/product/page/4/
extended-reading:https://www.bdmaee.net/catalyst-dabco-bx405-bx405-polyurethane-catalyst-dabco-bx405/
extended-reading:https://www.bdmaee.net/wp-content/uploads/2022/08/-BLX-11-polyurethane-foaming-catalyst-foaming-catalyst.pdf
extended-reading:https://www.cyclohexylamine.net/organotin-catalyst-t12-catalyst-t-12/
extended-reading:https://www.newtopchem.com/archives/44903
extended-reading:https://www.bdmaee.net/fascat-4201/

]]>